I had a 250gb SSD, it drove me nuts. 500gb would save you some headaches imo. Maybe drop the 4TB to 2TB. Unless you really need 4 TB of space. Are you a professional videographer or just a porn addict
How much Overclocking are you intending? Watercoolers are sort of a mixed bag as I found out from my Kraken, its technically quieter on silent than an air cooler, but the pumps make odd noises, instead of a constant hummmmm, so its often more noticeable. Performance wise they tend to be better, but not that much.
Getting a $60-70 Noctua air cooler and investing that $50-60 savings into the SSD or even spending an extra $50, or dropping the disc drive..., on top of that to boost the CPU up to the i7 would make more sense to me. DX12 is practically upon us, 8 threads will likely start making a difference. Expecially if you are doing workloads that would require 4TB of HDD space, unless its for recreational purposes
Otherwise it looks fine.